What it's used for
Piperacillin and tazobactam injection is used to treat intra-abdominal infections, nosocomial pneumonia, skin infections, female pelvic infections, and community-acquired pneumonia.
Source: U.S. FDA-approved prescribing information (openFDA).
Typical dosing
The usual daily dosage for adults with most infections is 3.375 g every six hours, while adults with nosocomial pneumonia typically receive 4.5 g every six hours along with an aminoglycoside.
Dosing shown here is the general FDA-labeled range. Your prescribing clinician determines the exact dose, form, and schedule for you — this is not a substitute for medical advice.
Common side effects
See full FDA prescribing information for the complete adverse reaction profile.
Covered strengths on the Tab $0 list
Covered at $0 with an active Tab membership when filled at a participating pharmacy nationwide or through mail order. A licensed clinician must prescribe the medication.
Related medications
Other antibiotics & antivirals medications covered at $0 with an active Tab membership.
Piperacillin/Tazobactam dosage and administration
Adult Patients with Indications Other than Nosocomial Pneumonia: The usual daily dosage of piperacillin and tazobactam for injection for adults is 3.375 grams every six hours totaling 13.5 grams (12.0 grams piperacillin and 1.5 grams tazobactam). ( 2.1 ) Adult Patients with Nosocomial Pneumonia : Initial presumptive treatment of patients with nosocomial pneumonia should start with piperacillin and tazobactam for injection at a dosage of 4.5 grams every six hours plus an aminoglycoside, totaling 18.0 grams (16.0 grams piperacillin and 2.0 grams tazobactam). ( 2.2 ) Adult Patients with Renal Impairment : Dosage in patients with renal impairment (creatinine clearance ≤40 mL/min) and dialysis patients should be reduced, based on the degree of renal impairment.
Excerpt from the FDA-approved prescribing information (openFDA), retrieved 2026-09-15. Your prescribing clinician decides the exact dose, form and schedule for you — this is not medical advice.
Piperacillin/Tazobactam side effects
The following clinically significant adverse reactions are described elsewhere in the labeling: Hypersensitivity Adverse Reactions [see Warnings and Precautions ( 5.1 )] Severe Cutaneous Adverse Reactions [see Warnings and Precautions ( 5.2 )] Hemophagocytic Lymphohistiocytosis [see Warnings and Precautions ( 5.3 )] Rhabdomyolysis [see Warnings and Precautions ( 5.4 )] Hematologic Adverse Reactions [see Warnings and Precautions ( 5.5 )] Central Nervous System Adverse Reactions [see Warnings and Precautions ( 5.6 )] Nephrotoxicity in Critically Ill Patients [see Warnings and Precautions ( 5.7 )] Clostridioides difficile- Associated Diarrhea [see Warnings and Precautions ( 5.9 )] The most common adverse reactions (incidence >5%) are diarrhea, constipation, nausea, headache, and insomnia.
Excerpt from the FDA-approved prescribing information (openFDA), retrieved 2026-09-15. This is not a complete list. Report side effects to your clinician, and seek care for anything severe or unexpected.
Piperacillin/Tazobactam drug interactions
Piperacillin and tazobactam administration can significantly reduce tobramycin concentrations in hemodialysis patients. Monitor tobramycin concentrations in these patients. ( 7.1 ) Probenecid prolongs the half-lives of piperacillin and tazobactam and should not be co-administered with piperacillin and tazobactam unless the benefit outweighs the risk. ( 7.2 ) Co-administration of piperacillin and tazobactam with vancomycin may increase the incidence of acute kidney injury. Monitor kidney function in patients receiving piperacillin and tazobactam and vancomycin. ( 7.3 ) Monitor coagulation parameters in patients receiving piperacillin and tazobactam and heparin or oral anticoagulants. ( 7.4 ) Piperacillin and tazobactam may prolong the neuromuscular blockade of vecuronium and other non-depolarizing neuromuscular blockers.
Excerpt from the FDA-approved prescribing information (openFDA), retrieved 2026-09-15. Tell your clinician and pharmacist about every medication, supplement and over-the-counter product you take.
Who should not take piperacillin/tazobactam
Piperacillin and tazobactam is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or beta-lactamase inhibitors. Patients with a history of allergic reactions to any of the penicillins, cephalosporins, or beta-lactamase inhibitors. ( 4 )
Excerpt from the FDA-approved prescribing information (openFDA), retrieved 2026-09-15. Whether this medication is appropriate for you is a clinical decision made by your prescribing clinician.
Common questions
Is piperacillin/Tazobactam covered at $0 with Tab?
Yes. Piperacillin/Tazobactam is on Tab's covered $0 generic list — every covered strength is $0 with an active membership, at participating pharmacies nationwide or by mail order.
Do I need insurance to get piperacillin/Tazobactam through Tab?
No. Tab is a membership, not insurance. Covered medications are $0 with an active membership whether or not you have a health plan.
How do I get a piperacillin/Tazobactam prescription with Tab?
Book a video visit with a licensed Tab clinician (unlimited visits are included with membership). If it's clinically appropriate, they send the prescription to your chosen participating pharmacy or by mail order.
What is the usual dose of piperacillin/tazobactam?
Adult Patients with Indications Other than Nosocomial Pneumonia: The usual daily dosage of piperacillin and tazobactam for injection for adults is 3.375 grams every six hours totaling 13.5 grams (12.0 grams piperacillin and 1.5 grams tazobactam). (FDA-approved label, retrieved 2026-09-15. Your clinician sets your dose.)
What are the side effects of piperacillin/tazobactam?
The following clinically significant adverse reactions are described elsewhere in the labeling: Hypersensitivity Adverse Reactions [see Warnings and Precautions ( 5.1 )] Severe Cutaneous Adverse Reactions [see Warnings and Precautions ( 5.2 )] Hemophagocytic Lymphohistiocytosis [see Warnings and Precautions ( 5.3 )] Rhabdomyolysis [see Warnings and Precautions ( 5.4 )] Hematologic Adverse Reactions [see Warnings and Precautions ( 5.5 )] Central Nervous System Adverse Reactions [see Warnings and Precautions ( 5.6 )] Nephrotoxicity in Critically Ill Patients [see Warnings and Precautions ( 5.7 )] Clostridioides difficile- Associated Diarrhea [see Warnings and Precautions ( 5.9 )] The most common adverse reactions (incidence >5%) are diarrhea, constipation, nausea, headache, and insomnia. (FDA-approved label, retrieved 2026-09-15.)
What interacts with piperacillin/tazobactam?
Piperacillin and tazobactam administration can significantly reduce tobramycin concentrations in hemodialysis patients. Monitor tobramycin concentrations in these patients. ( 7.1 ) Probenecid prolongs the half-lives of piperacillin and tazobactam and should not be co-administered with piperacillin and tazobactam unless the benefit outweighs the risk. (FDA-approved label, retrieved 2026-09-15. Tell your clinician about every medication and supplement you take.)
Piperacillin/Tazobactam is $0 on the covered list
Members pay $0 for covered generics at participating pharmacies nationwide or by mail order — plus unlimited virtual primary care, urgent care and dermatology visits. No insurance needed.
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